Title : Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling.

Pub. Date : 2016 May 12

PMID : 27176825






3 Functional Relationships(s)
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1 Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling. Daunorubicin AKT serine/threonine kinase 1 Homo sapiens
2 Additionally, IL-17A promoted resistance to daunorubicin via activation of Akt signaling and the PI3K/Akt inhibitor LY294002 or perifosine almost completely rescued daunorubicin-induced cell death in B-ALL cells. Daunorubicin AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSIONS: Our findings suggest that elevated Th17 cells secrete IL-17A by which promotes the proliferation and resistance to daunorubicin in B-ALL cells through activation of Akt signaling. Daunorubicin AKT serine/threonine kinase 1 Homo sapiens