Title : Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways.

Pub. Date : 2016 Jul

PMID : 27175819






2 Functional Relationships(s)
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1 The results demonstrated that lunasin (10-20 microM) effectively inhibited the migration and invasion activity and expression of matrix metalloproteinase (MMP)-2/-9 in both breast cancer cell lines. LUNASINE matrix metallopeptidase 2 Homo sapiens
2 Meanwhile, we also found that lunasin inhibited the phosphorylation of focal adhesion kinase (FAK), Src, Akt, ERK and nucleus translocation of NF-kappaB, which indicates that, possibly via competing with alphaVbeta3 or alphaVbeta5/alpha5beta1 integrin, lunasin suppresses the metastasis of breast cancer cells through integrin-mediated FAK/Akt/ERK and NF-kappaB signaling pathways followed by downregulation of the activity and expression of MMP-2/-9. LUNASINE matrix metallopeptidase 2 Homo sapiens