Pub. Date : 2016 Sep
PMID : 27157710
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies with heterologous expression systems have shown that the alpha4beta2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(alpha4)2(beta2)3] or three [(alpha4)3(beta2)2] copies of the alpha subunit in the receptor pentamer) which have different pharmacological and functional properties and are differently regulated by chronic nicotine treatment. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 2 | For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 3 | For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 4 | For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 5 | These data suggest that chronic nicotine exposure in vivo favors increased assembly of alpha4beta2 nAChR containing three beta2 subunits. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |