Title : Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes.

Pub. Date : 2016 Apr 15

PMID : 27155237






1 Functional Relationships(s)
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1 Our results indicate that as compared to compounds like carfilzomib, which target both the beta5 standard proteasome and the LMP7 immunoproteasome subunit, immunoproteasome-specific inhibitors with known anti-tumor capacity for MM cells might be advantageous for reducing cardiomyocyte death, when a combination therapy with DOX is envisaged. carfilzomib proteasome 20S subunit beta 8 Homo sapiens