Pub. Date : 2016 Nov
PMID : 27154922
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Interestingly, glutamate levels were significantly decreased in IDH1 mutant gliomas. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Conventional MRS detection of glutamate and 2HG resulted in a high diagnostic accuracy (sensitivity 72%, specificity 96%) for IDH1 mutant glioma. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | CONCLUSIONS: IDH1 mutations alter glutamate metabolism. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | Combining glutamate levels optimizes the 2HG-based monitoring of IDH1 mutations via MRS and represents a reliable clinical application for diagnosing IDH1 mutant gliomas. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 6 | Combining glutamate levels optimizes the 2HG-based monitoring of IDH1 mutations via MRS and represents a reliable clinical application for diagnosing IDH1 mutant gliomas. | Glutamic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |