Title : Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy.

Pub. Date : 2016 Jul

PMID : 27152679






2 Functional Relationships(s)
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1 Herein, we report site-specific in situ growth (SIG) of a PEG-like polymer, poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA), from the C-terminus of interferon-alpha to form a site-specific (C-terminal) and stoichiometric (1:1) POEGMA conjugate of interferon-alpha in high yield. Polyethylene Glycols interferon alpha Mus musculus
2 Herein, we report site-specific in situ growth (SIG) of a PEG-like polymer, poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA), from the C-terminus of interferon-alpha to form a site-specific (C-terminal) and stoichiometric (1:1) POEGMA conjugate of interferon-alpha in high yield. Polyethylene Glycols interferon alpha Mus musculus