Title : Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells.

Pub. Date : 2016 Jul 1

PMID : 27150432






1 Functional Relationships(s)
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1 Here, we show that pretreatment of A549 cells with the TRPV1 channel inhibitors capsazepine, AMG9810, SB366791 and BCTC suppressed the gamma-ray-induced activation of early DNA damage responses, i.e., activation of the protein kinase ataxia-telangiectasia mutated (ATM) and accumulation of p53-binding protein 1 (53BP1). 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide transient receptor potential cation channel subfamily V member 1 Homo sapiens