Title : Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines.

Pub. Date : 2016 Aug 25

PMID : 27149037






1 Functional Relationships(s)
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1 Thus, maslinic acid derived N-[2beta,3beta-di-O-acetyl-17beta-amino-28-norolean-12-en-17-yl]phenylurea (45) gave best results showing EC50 = 0.9 muM (for A2780 ovarian cancer cells) with EC50 > 120 muM for fibroblasts (NIH 3T3) and triggered apoptosis while caspase-3 was not activated by this compound. maslinic acid caspase 3 Homo sapiens