Title : Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway.

Pub. Date : 2016 Jun 7

PMID : 27144340






2 Functional Relationships(s)
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1 Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway. Metformin insulin like growth factor 1 Homo sapiens
2 Furthermore, the addition of IGF-1 to crizotinib-sensitive H2228 cells induced crizotinib resistance, which was overcome by metformin. Metformin insulin like growth factor 1 Homo sapiens