Title : Loss of Bmal1 decreases oocyte fertilization, early embryo development and implantation potential in female mice.

Pub. Date : 2016 Oct

PMID : 27140828






2 Functional Relationships(s)
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1 The intracellular ROS levels in the ovary on proestrus day and in the oviduct on metestrus day increased significantly in Bmal1-/- mice compared with that of Bmal1+/+ mice. Reactive Oxygen Species aryl hydrocarbon receptor nuclear translocator-like Mus musculus
2 Deletion of the core biological clock gene Bmal1 significantly decreases oocyte fertilization rate, early embryo development and implantation potential in female mice, and these may be possibly caused by excess ROS levels generated in ovary and oviduct. Reactive Oxygen Species aryl hydrocarbon receptor nuclear translocator-like Mus musculus