Pub. Date : 2016 Apr 28
PMID : 27136586
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27. | ovatodiolide | SMAD specific E3 ubiquitin protein ligase 2 | Homo sapiens |
| 2 | Ova dose-dependently downregulated the expression of stemness genes, octamer-binding transcription factor 4 (Oct4) and Nanog, as well as heat shock protein 27 (Hsp27), but upregulated SMAD ubiquitin regulatory factor 2 (SMURF2) in mammosphere cells derived from AS-B145 or BT-474. | ovatodiolide | SMAD specific E3 ubiquitin protein ligase 2 | Homo sapiens |
| 3 | Ova dose-dependently downregulated the expression of stemness genes, octamer-binding transcription factor 4 (Oct4) and Nanog, as well as heat shock protein 27 (Hsp27), but upregulated SMAD ubiquitin regulatory factor 2 (SMURF2) in mammosphere cells derived from AS-B145 or BT-474. | ovatodiolide | SMAD specific E3 ubiquitin protein ligase 2 | Homo sapiens |
| 4 | Overexpression of Hsp27 or knockdown of SMURF2 in AS-B145 cells diminished the therapeutic effect of ovatodiolide in the suppression of mammosphere formation. | ovatodiolide | SMAD specific E3 ubiquitin protein ligase 2 | Homo sapiens |
| 5 | In summary, our data reveal that Ova displays an anti-CSC activity through SMURF2-mediated downregulation of Hsp27. | ovatodiolide | SMAD specific E3 ubiquitin protein ligase 2 | Homo sapiens |