Title : Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands.

Pub. Date : 2016 Aug 8

PMID : 27128184






2 Functional Relationships(s)
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1 Based on the SAR of amidine-derived analogs, the novel heterobivalent compound 30, targeting both hepsin and PSMA, was synthesized by linking compound 18 with Lys-urea-Glu, the key scaffold for the specific binding to PSMA, followed by the conjugation of the optical dye SulfoCy7. sulfocy7 folate hydrolase 1 Homo sapiens
2 Based on the SAR of amidine-derived analogs, the novel heterobivalent compound 30, targeting both hepsin and PSMA, was synthesized by linking compound 18 with Lys-urea-Glu, the key scaffold for the specific binding to PSMA, followed by the conjugation of the optical dye SulfoCy7. sulfocy7 folate hydrolase 1 Homo sapiens