Title : The effects of CYP3A4 induction and inhibition on the pharmacokinetics of alisporivir in humans.

Pub. Date : 2015 Jan

PMID : 27128001






2 Functional Relationships(s)
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1 In vitro data suggest that alisporivir is a substrate and inhibitor of CYP3A4 and P-gp. alisporivir phosphoglycolate phosphatase Homo sapiens
2 Hence, the potential for drug-drug interactions when alisporivir is co-administered with CYP3A4 and/or P-gp inhibitors such as ketoconazole, azithromycin and CYP3A4 inducers such as rifampin were evaluated in three separate clinical studies. alisporivir phosphoglycolate phosphatase Homo sapiens