Title : IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression.

Pub. Date : 2016 Oct

PMID : 27116977






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Decitabine increases NKG2D ligand expression and restores NK-mediated lysis of IDH mutant cells in an NKG2D-dependent manner. Decitabine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Decitabine-mediated hypomethylation restores ULBP1 and ULBP3 expression in IDH mutant glioma cells and may provide a clinically useful method to sensitize IDH mutant gliomas to NK cell-mediated immune surveillance in patients with IDH mutated diffuse gliomas. Decitabine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 Decitabine-mediated hypomethylation restores ULBP1 and ULBP3 expression in IDH mutant glioma cells and may provide a clinically useful method to sensitize IDH mutant gliomas to NK cell-mediated immune surveillance in patients with IDH mutated diffuse gliomas. Decitabine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
4 Decitabine-mediated hypomethylation restores ULBP1 and ULBP3 expression in IDH mutant glioma cells and may provide a clinically useful method to sensitize IDH mutant gliomas to NK cell-mediated immune surveillance in patients with IDH mutated diffuse gliomas. Decitabine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens