Title : Brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive haematologic malignancies and hepatic or renal impairment.

Pub. Date : 2016 Sep

PMID : 27115790






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Severe renal impairment (creatinine clearance <30 ml min(-1) ; n = 3) decreased ADC exposures (0.71 [0.54, 0.94]) and increased MMAE exposures (1.90 [0.85, 4.21]). Creatinine CD59 molecule (CD59 blood group) Homo sapiens