Pub. Date : 2016 Jun 3
PMID : 27103438
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Here, we demonstrate for the first time that TSPO ligands, especially Ro5-4864, potently suppressed ATP-induced NLRP3 inflammasome activation in THP-1 and BMDM cells. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Ro5-4864 efficiently attenuated NLRP3 translocation to mitochondria, inflammasome assembly/oligomerization, activation of caspase-1, and subsequent secretion of the mature forms of interleukin-1beta and -18. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Ro5-4864 also reduced the production of mitochondrial superoxide and preserved the mitochondrial membrane potential in ATP-treated cells, suggesting that Ro5-4864 may act on mitochondria or more upstream targets in NLRP3 inflammasome signaling. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Ro5-4864 also reduced the production of mitochondrial superoxide and preserved the mitochondrial membrane potential in ATP-treated cells, suggesting that Ro5-4864 may act on mitochondria or more upstream targets in NLRP3 inflammasome signaling. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Collectively, our novel findings demonstrate that Ro5-4864 effectively inhibited ATP-induced NLRP3 inflammasome activation through the prevention of mitochondrial perturbation. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Our results indicate Ro5-4864 as a promising candidate for the treatment of NLRP3 inflammasome-related diseases. | 4'-chlorodiazepam | NLR family pyrin domain containing 3 | Homo sapiens |