Pub. Date : 1989 Feb
PMID : 2710136
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit. | Methyltestosterone | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 2 | The antagonist 17 alpha-methyltestosterone competes with agonist for binding to the 10 S cytosolic receptor but does not appear to promote dissociation of the oligomer, thus inhibiting agonist-mediated nuclear actions of the glucocorticoid receptor. | Methyltestosterone | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |