Title : Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase.

Pub. Date : 2016 Nov

PMID : 27095537






1 Functional Relationships(s)
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1 FAU, a pyrimidine nucleotide analogue, is a prodrug bioactivated by intracellular thymidylate synthase to form FMAU, which is incorporated into DNA, causing cell death. Pyrimidine Nucleotides FAU ubiquitin like and ribosomal protein S30 fusion Homo sapiens