Title : Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure.

Pub. Date : 2016

PMID : 27094549






3 Functional Relationships(s)
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1 The expression of Bdnf and Pdyn (qPCR) was increased after morphine treatment and incision. Morphine prodynorphin Mus musculus
2 Chromatin immunoprecipitation assays demonstrated that the Pdyn and Bdnf promoters were more strongly associated with acetylated H3K9 after morphine plus incision than in the morphine or incision alone groups. Morphine prodynorphin Mus musculus
3 Chromatin immunoprecipitation assays demonstrated that the Pdyn and Bdnf promoters were more strongly associated with acetylated H3K9 after morphine plus incision than in the morphine or incision alone groups. Morphine prodynorphin Mus musculus