Title : Ursolic acid and rosiglitazone combination improves insulin sensitivity by increasing the skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice.

Pub. Date : 2016 Jun

PMID : 27090933






2 Functional Relationships(s)
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1 Further, combination treatment (UA/RSG) stimulated the IRS-1, PI3-kinase, Akt, and GLUT 4 translocation. ursolic acid thymoma viral proto-oncogene 1 Mus musculus
2 These results strongly suggest that combination treatment (UA/RSG) activates IRS-PI3-kinase-Akt-dependent signaling pathways to induce GLUT 4 translocation and increases the expression of insulin receptor to improve glucose intolerance. ursolic acid thymoma viral proto-oncogene 1 Mus musculus