Pub. Date : 2016 Apr 28
PMID : 27088648
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription. | Cyproheptadine | SET domain containing 7, histone lysine methyltransferase | Homo sapiens |
| 2 | Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription. | Cyproheptadine | SET domain containing 7, histone lysine methyltransferase | Homo sapiens |
| 3 | We identified cyproheptadine, a clinically approved antiallergy drug, as a Set7/9 inhibitor in a high-throughput screen using a fluorogenic substrate-based HMT assay. | Cyproheptadine | SET domain containing 7, histone lysine methyltransferase | Homo sapiens |
| 4 | Kinetic and X-ray crystallographic analyses revealed that cyproheptadine binds in the substrate-binding pocket of Set7/9 and inhibits its enzymatic activity by competing with the methyl group acceptor. | Cyproheptadine | SET domain containing 7, histone lysine methyltransferase | Homo sapiens |