Pub. Date : 2016 Jun 1
PMID : 27084388
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2-EP3 signaling exacerbates intracerebral hemorrhage outcomes in 24-mo-old mice. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 2 | EP3 is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2-EP3 axis exacerbates ICH outcomes in young mice. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 3 | EP3 is the most abundant EP receptor in the brain and we have previously shown that signaling through the PGE2-EP3 axis exacerbates ICH outcomes in young mice. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 4 | Using this aged cohort of mice, we have confirmed and extended our previous results in young mice demonstrating the deleterious role of the PGE2-EP3 signaling axis in modulating brain injury and functional recovery after ICH, further supporting the notion of the EP3 receptor as a putative therapeutic avenue for the treatment of ICH. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |