Title : Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons.

Pub. Date : 2016 Apr 14

PMID : 27080129






1 Functional Relationships(s)
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1 CONCLUSIONS: Our data is the first to demonstrate the direct link of nuclear morphology and SOC calcium deregulation to mutant huntingtin protein expression in iPSCs-derived neurons with disease-mimetic hallmarks, providing a valuable tool for identification of candidate anti-HD drugs. Calcium huntingtin Homo sapiens