Title : Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation.

Pub. Date : 2016 Apr 14

PMID : 27074918






2 Functional Relationships(s)
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1 In MCF7 cells, a human breast cancer cell line, MSNBA competitively inhibited GLUT5 fructose uptake with a KI of 3.2 +- 0.4 muM. Fructose solute carrier family 2 member 5 Homo sapiens
2 Thus, MSNBA is a selective and potent inhibitor of fructose transport via GLUT5, and the first chemical probe for this transporter. Fructose solute carrier family 2 member 5 Homo sapiens