Title : Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells.

Pub. Date : 2016 Apr

PMID : 27073554






1 Functional Relationships(s)
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1 Metformin (MET), the first-line drug for treating diabetes, it has been proved that it reduces AKT activation and selectively kills cancer stem cells, but whether it can potentiate the cytotoxicity of TMZ for GSCs remains unknown. Metformin AKT serine/threonine kinase 1 Homo sapiens