Title : Resveratrol preconditioning protects hepatocytes against hepatic ischemia reperfusion injury via Toll-like receptor 4/nuclear factor-κB signaling pathway in vitro and in vivo.

Pub. Date : 2016 Jun

PMID : 27064547






1 Functional Relationships(s)
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1 In vivo assays revealed that resveratrol reduced levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and liver pathological changes, while it alleviated hepatocyte apoptosis, negatively mediated the production of TNF-alpha and IL-1beta in serum, and reversed TLR4/NF-kappaB signaling pathway caused by hepatic ischemia/reperfusion stimulation in liver tissues. Resveratrol interleukin 1 beta Rattus norvegicus