Title : Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation.

Pub. Date : 2016 May 31

PMID : 27058757






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1 Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-beta-induced cancer-associated fibroblast differentiation. Glycosides transforming growth factor beta 1 Homo sapiens
2 Herein, we report that multiple cardiac glycoside compounds, including digoxin, are able to inhibit TGF-beta-induced fibronectin expression at low nanomolar concentrations without undesirable cell toxicity. Glycosides transforming growth factor beta 1 Homo sapiens