Title : Effect of n-3 fatty acids on the expression of inflammatory genes in THP-1 macrophages.

Pub. Date : 2016 Apr 5

PMID : 27044314






3 Functional Relationships(s)
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1 The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
2 The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages. Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens
3 RESULTS: 50 muM, 10 muM EPA and 50 muM EPA + DHA decreased the expression of genes involved in the NF-kappaB pathway (MAPK, AKT1, and NFKB). Docosahexaenoic Acids AKT serine/threonine kinase 1 Homo sapiens