Title : Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1.

Pub. Date : 2016

PMID : 27033734






1 Functional Relationships(s)
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1 Compound 12 was the most potent inducer in this new series, with a concentration that doubles the specific activity of NQO1 (CD value) of 70 nM. Cadmium NAD(P)H quinone dehydrogenase 1 Homo sapiens