Title : The formation of catalytically competent enzyme-substrate complex is not a bottleneck in lesion excision by human alkyladenine DNA glycosylase.

Pub. Date : 2017 Apr

PMID : 27025273






1 Functional Relationships(s)
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1 To understand better, how the step of nucleotide eversion influences the overall catalytic process, we performed a pre-steady-state kinetic analysis of AAG interaction with specific DNA-substrates, 13-base pair duplexes containing in the 7th position 1-N6-ethenoadenine (epsilonA), hypoxanthine (Hx), and the stable product analogue tetrahydrofuran (F). 1,N(6)-ethenoadenine N-methylpurine DNA glycosylase Homo sapiens