Pub. Date : 2016 Aug
PMID : 27015352
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. | Sorafenib | metallothionein 1G | Homo sapiens |
| 2 | Here, we show that metallothionein (MT)-1G is a critical regulator and promising therapeutic target of sorafenib resistance in human HCC cells. | Sorafenib | metallothionein 1G | Homo sapiens |
| 3 | The expression of MT-1G messenger RNA and protein is remarkably induced by sorafenib but not other clinically relevant kinase inhibitors (e.g., erlotinib, gefitinib, tivantinib, vemurafenib, selumetinib, imatinib, masitinib, and ponatinib). | Sorafenib | metallothionein 1G | Homo sapiens |
| 4 | Activation of the transcription factor nuclear factor erythroid 2-related factor 2, but not p53 and hypoxia-inducible factor 1-alpha, is essential for induction of MT-1G expression following sorafenib treatment. | Sorafenib | metallothionein 1G | Homo sapiens |
| 5 | Importantly, genetic and pharmacological inhibition of MT-1G enhances the anticancer activity of sorafenib in vitro and in tumor xenograft models. | Sorafenib | metallothionein 1G | Homo sapiens |
| 6 | The molecular mechanisms underlying the action of MT-1G in sorafenib resistance involve the inhibition of ferroptosis, a novel form of regulated cell death. | Sorafenib | metallothionein 1G | Homo sapiens |
| 7 | Knockdown of MT-1G by RNA interference increases glutathione depletion and lipid peroxidation, which contributes to sorafenib-induced ferroptosis. | Sorafenib | metallothionein 1G | Homo sapiens |
| 8 | CONCLUSION: These findings demonstrate a novel molecular mechanism of sorafenib resistance and suggest that MT-1G is a new regulator of ferroptosis in HCC cells. | Sorafenib | metallothionein 1G | Homo sapiens |