Title : Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling.

Pub. Date : 2016 Aug

PMID : 27002602






2 Functional Relationships(s)
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1 In both cases, the effect of R-OME was smaller compared to that of the S-OME and a certain degree of enantioselectivity of CYP17A1 and CYP21A2 was suggested. r-ome cytochrome P450 family 21 subfamily A member 2 Homo sapiens
2 Docking indicated that the N-containing rings of OME possibly could interact with the iron atom of the heme for S-OME in CYP17A1 and S- and R-OME in CYP21A2. r-ome cytochrome P450 family 21 subfamily A member 2 Homo sapiens