Title : Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18).

Pub. Date : 2016

PMID : 26998610






3 Functional Relationships(s)
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1 The effect of 17beta-Estradiol can be mimicked by the GPER1 agonist, G1, and also by tamoxifen and ICI 182,780 which activate GPER1 in a variety of other preparations. Estradiol G protein-coupled estrogen receptor 1 Mus musculus
2 The effect of 17beta-Estradiol can be mimicked by the GPER1 agonist, G1, and also by tamoxifen and ICI 182,780 which activate GPER1 in a variety of other preparations. Estradiol G protein-coupled estrogen receptor 1 Mus musculus
3 The response is not mimicked by the application of the classical estrogen receptor agonists, PPT, (an ERalpha agonist) or DPN, (an ERbeta agonist), further suggesting that this effect of 17beta-Estradiol is mediated through the activation of GPER1. Estradiol G protein-coupled estrogen receptor 1 Mus musculus