Title : PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes.

Pub. Date : 2016 Jun

PMID : 26995650






2 Functional Relationships(s)
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Protein Name
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1 The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
2 In WT non-injected and WT-STZ mice, EP3 activation with sulprostone (PGE2 analogue) abrogated AVP-mediated water reabsorption; this effect was absent in mice lacking EP3. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus