Title : Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

Pub. Date : 2016 May

PMID : 26984301






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1 The BMD-covariate approach revealed tissue-specific differences in the induction of lacZ transgene mutations in Muta Mouse specimens exposed to benzo[a]pyrene (BaP), with the results permitting the formulation of mechanistic hypotheses regarding the observed potency ranking. Benzo(a)pyrene prohibitin 2 Mus musculus