Title : Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway.

Pub. Date : 2016 May

PMID : 26983669






3 Functional Relationships(s)
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1 Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway. sinomenine C-X-C motif chemokine receptor 4 Homo sapiens
2 Sinomenine inhibited invasion by suppressing CXCR4 and STAT3 phosphorylation then downregulating the expression of MMP-2, MMP-9, RANKL, VEGF downstream. sinomenine C-X-C motif chemokine receptor 4 Homo sapiens
3 Taken together, our results revealed that sinomenine caused S phase arrest, inhibited invasion and metastasis via suppressing the CXCR4-STAT3 pathway and then osteoclastogenesis-mediated bone destruction and neovascularization in osteosarcoma. sinomenine C-X-C motif chemokine receptor 4 Homo sapiens