Title : Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.

Pub. Date : 1989 Oct

PMID : 2697686






1 Functional Relationships(s)
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1 In the RINm5F cells there was a dose-dependent inhibition of the cell replication to approximately 50% of the controls in cells exposed to 25 U/ml rIL-1 beta for 48 h. This was also accompanied by an increased cell death, as measured by trypan blue inclusion (controls 13% and rIL-1 beta treated cells 25%). Trypan Blue interleukin 1 beta Rattus norvegicus