Title : EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.

Pub. Date : 2016

PMID : 26973857






2 Functional Relationships(s)
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1 The tumor suppressor, p53 is central for apoptotic response to multiple DNA damaging agents used to treat aggressive B-cell lymphomas, including etoposide. Etoposide tumor protein p53 Homo sapiens
2 Using B-cell lymphoma cell lines resistant to etoposide induced cell death; we show that p53 is dramatically down regulated and MDMX, a negative regulator of p53, is significantly up regulated. Etoposide tumor protein p53 Homo sapiens