Title : Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways.

Pub. Date : 2016 Apr

PMID : 26972495






1 Functional Relationships(s)
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1 Treatment of cultured skeletal muscle cells with rutaecarpine (20-180 mumol/L) or metformin (20 mumol/L) promoted the phosphorylation of AMPK and ACC2, and increased glucose uptake. Metformin acetyl-CoA carboxylase beta Rattus norvegicus