Pub. Date : 2016 Apr 4
PMID : 26951332
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that treatment with all-trans retinoic acid (ATRA) at clinically achievable doses markedly enhanced terminal granulocytic differentiation in AML cell lines, primary patient samples, and a xenograft mouse model carrying mutant IDH1. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | We show that treatment with all-trans retinoic acid (ATRA) at clinically achievable doses markedly enhanced terminal granulocytic differentiation in AML cell lines, primary patient samples, and a xenograft mouse model carrying mutant IDH1. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Moreover, treatment with a cell-permeable form of 2-HG sensitized wild-type IDH1 AML cells to ATRA-induced myeloid differentiation, whereas inhibition of 2-HG production significantly reduced ATRA effects in mutant IDH1 cells. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | ATRA treatment specifically decreased cell viability and induced apoptosis of mutant IDH1 blasts in vitro. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | ATRA also reduced tumor burden of mutant IDH1 AML cells xenografted in NOD-Scid-IL2rgamma(null)mice and markedly increased overall survival, revealing a potent antileukemic effect of ATRA in the presence of IDH1 mutation. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 6 | ATRA also reduced tumor burden of mutant IDH1 AML cells xenografted in NOD-Scid-IL2rgamma(null)mice and markedly increased overall survival, revealing a potent antileukemic effect of ATRA in the presence of IDH1 mutation. | Tretinoin | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |