Title : Differential actıvation and expression of insulin receptor substrate 1 (IRS1) in mononuclear cells of type 2 diabetes patients after insulin stimulation.

Pub. Date : 2016 Feb 4

PMID : 26950447






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IRS1 is the best studied member of this family and insulin-induced Tyrosine phosphorylation of (YXXM) motifs provides docking site for SH2 domain-containing proteins. Tyrosine insulin receptor substrate 1 Homo sapiens
2 Although, we did not detect any mutations at/or near the YXXM coding regions in patients" DNA, immunprecipitation analysis of IRS1 indicated decreased levels of expression and tyrosine phosphorylation of IRS1 in patient"s samples compared to that of healthy controls. Tyrosine insulin receptor substrate 1 Homo sapiens
3 Although, we did not detect any mutations at/or near the YXXM coding regions in patients" DNA, immunprecipitation analysis of IRS1 indicated decreased levels of expression and tyrosine phosphorylation of IRS1 in patient"s samples compared to that of healthy controls. Tyrosine insulin receptor substrate 1 Homo sapiens