Pub. Date : 2016 Apr
PMID : 26948085
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, hyperoside dose-dependently inhibited the phosphorylation of Akt, mTOR, p70S6K and 4E-BP1, but increased the phosphorylation of ERK1/2 in A549 cells. | hyperoside | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Insulin (200 nmol/L) markedly enhanced the phosphorylation of Akt and decreased LC3-II expression in A549 cells, which were reversed by pretreatment with hyperoside, whereas the MEK1/2 inhibitor U0126 (20 mumol/L) did not blocked hyperoside-induced LC3-II expression. | hyperoside | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Insulin (200 nmol/L) markedly enhanced the phosphorylation of Akt and decreased LC3-II expression in A549 cells, which were reversed by pretreatment with hyperoside, whereas the MEK1/2 inhibitor U0126 (20 mumol/L) did not blocked hyperoside-induced LC3-II expression. | hyperoside | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The autophagy is induced through inhibiting the Akt/mTOR/p70S6K signal pathways, which contributes to anticancer actions of hyperoside. | hyperoside | AKT serine/threonine kinase 1 | Homo sapiens |