Title : Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells.

Pub. Date : 2016 May 28

PMID : 26944210






2 Functional Relationships(s)
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1 Indeed, genetic silencing of key components of necroptosis such as Receptor-Interacting Protein (RIP)3 or mixed lineage kinase domain-like (MLKL) in parallel with administration of zVAD.fmk provides a significantly better protection against BV6/5AC-induced cell death compared to the use of zVAD.fmk alone. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mixed lineage kinase domain like pseudokinase Homo sapiens
2 Indeed, genetic silencing of key components of necroptosis such as Receptor-Interacting Protein (RIP)3 or mixed lineage kinase domain-like (MLKL) in parallel with administration of zVAD.fmk provides a significantly better protection against BV6/5AC-induced cell death compared to the use of zVAD.fmk alone. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mixed lineage kinase domain like pseudokinase Homo sapiens