Title : Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells.

Pub. Date : 2016

PMID : 26938869






4 Functional Relationships(s)
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1 Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Steroids sulfotransferase family 2A member 1 Homo sapiens
2 Taken together, these results are consistent with the effects of DHEAS being mediated through a membrane-bound G-protein-coupled receptor interacting with Gnalpha11 in a signaling pathway that resembles the non-classical signaling pathways of steroid hormones. Steroids sulfotransferase family 2A member 1 Homo sapiens
3 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids sulfotransferase family 2A member 1 Homo sapiens
4 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids sulfotransferase family 2A member 1 Homo sapiens