Pub. Date : 2016 Apr 5
PMID : 26934443
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53. | Ganciclovir | tumor protein p53 | Homo sapiens |
| 2 | We hypothesize that the efficacy of HSV-TK/GCV therapy is at least partially dependent on p53 status in hepatocellular carcinoma (HCC) patients. | Ganciclovir | tumor protein p53 | Homo sapiens |
| 3 | Similarly, ASPP2 reduced survival in rAdV-TK/GCV-treated primary HCC cells expressing p53 wild-type but not a p53 R249S mutant. | Ganciclovir | tumor protein p53 | Homo sapiens |
| 4 | Mutated p53 was unable to bind to ASPP2, suggesting that the increase in rAdV-TK/GCV-induced cell death resulting from ASPP2 overexpression was dependent on its interaction with p53. | Ganciclovir | tumor protein p53 | Homo sapiens |
| 5 | Mutated p53 was unable to bind to ASPP2, suggesting that the increase in rAdV-TK/GCV-induced cell death resulting from ASPP2 overexpression was dependent on its interaction with p53. | Ganciclovir | tumor protein p53 | Homo sapiens |