Title : BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration.

Pub. Date : 2016 May

PMID : 26929154






1 Functional Relationships(s)
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1 Lentivirus-mediated BMP7 over-expression induced differentiation of BMSCs into an NP phenotype, as indicated by expression of the NP markers collagen type II, aggrecan, SOX9 and keratins 8 and 19, increased the content of glycosaminoglycan, and up-regulated beta-1,3-glucuronosyl transferase 1, a regulator of chondroitin sulfate synthesis in NP cells. Chondroitin Sulfates bone morphogenetic protein 7 Oryctolagus cuniculus