Title : Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.

Pub. Date : 2016 May

PMID : 26928591






2 Functional Relationships(s)
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1 The iron coordination and spin state of the Cygb heme group are sensitive to oxidation of two cysteine residues (Cys38/Cys83) and/or the binding of free fatty acids. Iron cytoglobin Homo sapiens
2 Searching for physiologically relevant lipid regulators of Cygb, here we report that anionic phospholipids, particularly phosphatidylinositolphosphates, affect structural organization of the protein and modulate its iron state and peroxidase activity both conjointly and/or independently of cysteine oxidation. Iron cytoglobin Homo sapiens