Title : Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells.

Pub. Date : 2016

PMID : 26925782






2 Functional Relationships(s)
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1 The present study also demonstrated that hyperactivation of PI3K/Aktpathway is closely associated with cisplatin resistance by regulating the Bax-mitochondria-mediated apoptosis pathway in human lung cancer. Cisplatin BCL2 associated X, apoptosis regulator Homo sapiens
2 Inhibition of PI3K/Aktactivity in A549/DDP cells and H460/DDP cells could reverse cisplatin resistance by enhancing the effect of cisplatin on Bax oligomerization and release of Cytochrome C, allowing activation of the caspase-mediated apoptosis pathway. Cisplatin BCL2 associated X, apoptosis regulator Homo sapiens