Pub. Date : 2016
PMID : 26925782
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The present study also demonstrated that hyperactivation of PI3K/Aktpathway is closely associated with cisplatin resistance by regulating the Bax-mitochondria-mediated apoptosis pathway in human lung cancer. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |
2 | Inhibition of PI3K/Aktactivity in A549/DDP cells and H460/DDP cells could reverse cisplatin resistance by enhancing the effect of cisplatin on Bax oligomerization and release of Cytochrome C, allowing activation of the caspase-mediated apoptosis pathway. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |