Title : Protective effect of chlorpromazine against the lethality of interleukin 1 in adrenalectomized or actinomycin D-sensitized mice.

Pub. Date : 1989 Dec 29

PMID : 2692568






3 Functional Relationships(s)
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1 We have tested the effect of dexamethasone (DEX) and chlorpromazine (CPZ) on the lethal effect of IL-1, TNF and endotoxin. Chlorpromazine interleukin 1 complex Mus musculus
2 We have tested the effect of dexamethasone (DEX) and chlorpromazine (CPZ) on the lethal effect of IL-1, TNF and endotoxin. Chlorpromazine interleukin 1 complex Mus musculus
3 CPZ (4 mg/kg) was found to protect mice against IL-1 and endotoxin toxicity in all cases, while DEX had a protective effect only in adrenalectomized mice. Chlorpromazine interleukin 1 complex Mus musculus