Title : Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice.

Pub. Date : 2016 May

PMID : 26921684






4 Functional Relationships(s)
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1 Adipose tissue can store over 50% of whole-body cholesterol; however, the physiological role of adipose tissue in cholesterol metabolism and atherogenesis has not been directly assessed. Cholesterol WD and tetratricopeptide repeats 1 Mus musculus
2 Adipose tissue can store over 50% of whole-body cholesterol; however, the physiological role of adipose tissue in cholesterol metabolism and atherogenesis has not been directly assessed. Cholesterol WD and tetratricopeptide repeats 1 Mus musculus
3 Our results provide direct evidence, for the first time, that the adipose tissue plays a critical role in the clearance of plasma cholesterol. Cholesterol WD and tetratricopeptide repeats 1 Mus musculus
4 Our results also reveal a previously unappreciated strong link between adipose tissue and LDLR in plasma cholesterol metabolism. Cholesterol WD and tetratricopeptide repeats 1 Mus musculus